Issue 1, 2003
From the journal:

Chemical Communications

Site-specific cleavage of human telomerase RNA using PNA-neocuproine·Zn(ii) derivatives†

Andrew Whitney,a   Gérald Gavorya  and  Shankar Balasubramanian*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

Abstract

Here we report the synthesis of a novel PNA based neocuproine·Zn RNA cleaving agent; we demonstrate that such agents sequence specifically cleave a synthetic RNA target and in particular the RNA component of human telomerase.

Graphical abstract: Site-specific cleavage of human telomerase RNA using PNA-neocuproine·Zn(ii) derivatives

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Article information

DOI
https://doi.org/10.1039/B210135A
Article type
Communication
Submitted
16 Oct 2002
Accepted
11 Nov 2002
First published
26 Nov 2002

Chem. Commun., 2003, 36-37

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Site-specific cleavage of human telomerase RNA using PNA-neocuproine·Zn(II) derivatives

A. Whitney, G. Gavory and S. Balasubramanian, Chem. Commun., 2003, 36 DOI: 10.1039/B210135A

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