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Issue 2, 2003
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Singlet oxygen-induced signaling effects in mammalian cells

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Abstract

Singlet oxygen, an electronically excited form of molecular oxygen, may be generated photochemically or in dark reactions in vivo. Singlet oxygen is not only toxic to cells and impairs signaling events but is also capable of eliciting a cellular stress response. The signaling processes initiated in this response include the activation of mitogen-activated protein kinases. Two possible activation mechanisms of signaling pathways by singlet oxygen are the generation of positive regulators as well as the inactivation of negative regulators.

Graphical abstract: Singlet oxygen-induced signaling effects in mammalian cells

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Publication details

The article was received on 01 Nov 2002, accepted on 09 Dec 2002 and first published on 07 Jan 2003


Article type: Perspective
DOI: 10.1039/B210750C
Photochem. Photobiol. Sci., 2003,2, 88-94

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    Singlet oxygen-induced signaling effects in mammalian cells

    L. Klotz, K. Kröncke and H. Sies, Photochem. Photobiol. Sci., 2003, 2, 88
    DOI: 10.1039/B210750C

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