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Issue 4, 2003
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Enzymatic optical resolution viaacylation–hydrolysis on a solid support

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By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis–hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.

Graphical abstract: Enzymatic optical resolution via acylation–hydrolysis on a solid support

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Article information

04 Dec 2002
17 Jan 2003
First published
28 Jan 2003

Org. Biomol. Chem., 2003,1, 621-622
Article type

Enzymatic optical resolution via acylationhydrolysis on a solid support

R. V. Ulijn, N. Bisek and S. L. Flitsch, Org. Biomol. Chem., 2003, 1, 621
DOI: 10.1039/B211887D

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