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Issue 22, 2003
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Diversity-oriented synthesis; a challenge for synthetic chemists

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Abstract

The efficient, simultaneous synthesis of structurally diverse compounds, better known as diversity-oriented synthesis (DOS), is not obvious, and remains a challenge to synthetic chemistry. This personal account details why DOS has such enormous implications for the discovery of small molecules with desired properties, such as catalysts, synthetic reagents, biological probes and new drugs. Also, I describe the evolution behind the current state-of-play of DOS.

Graphical abstract: Diversity-oriented synthesis; a challenge for synthetic chemists

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Publication details

The article was received on 03 Sep 2003, accepted on 24 Sep 2003 and first published on 13 Oct 2003


Article type: Emerging Area
DOI: 10.1039/B310752N
Org. Biomol. Chem., 2003,1, 3867-3870

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    Diversity-oriented synthesis; a challenge for synthetic chemists

    D. R. Spring, Org. Biomol. Chem., 2003, 1, 3867
    DOI: 10.1039/B310752N

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