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Issue 1, 2003
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Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

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Abstract

A fluorescent probe for the detection of a metallo-β-lactamase (IMP-1), N-[2-(5-dimethylaminonaphthalen-1-ylsulfonylamino)ethyl]-3-mercaptopropionamide (DansylC2SH), 1, was designed based on combining the inhibitory function of mercaptocarboxylate and a fluorophore. The binding of 1 to IMP-1 was investigated by fluorescence spectroscopy. Compound 1 can act as fluorescent probe for detecting IMP-1 selectively.

Graphical abstract: Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

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Publication details

The article was received on 17 Sep 2002, accepted on 21 Oct 2002 and first published on 08 Nov 2002


Article type: Communication
DOI: 10.1039/B209086D
Org. Biomol. Chem., 2003,1, 17-20

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    Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

    H. Kurosaki, H. Yasuzawa, Y. Yamaguchi, W. Jin, Y. Arakawa and M. Goto, Org. Biomol. Chem., 2003, 1, 17
    DOI: 10.1039/B209086D

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