Issue 1, 2003
From the journal:

Organic & Biomolecular Chemistry

Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups†

Hiromasa Kurosaki,a   Hisami Yasuzawa,a   Yoshihiro Yamaguchi,a   Wanchun Jin,a   Yoshichika Arakawab  and  Masafumi Goto*a  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan
E-mail: gotomphi@gpo.kumamoto-u.ac.jp
Fax: +81-96-371-4314
Tel: +81-96-371-4310

b Department of Bacterial and Blood Products, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashi-Murayama, Tokyo 208-0011, Japan
E-mail: yarakawa@nih.go.jp
Fax: +81-42-561-7173
Tel: +81-42-561-0771

Abstract

A fluorescent probe for the detection of a metallo-β-lactamase (IMP-1), N-[2-(5-dimethylaminonaphthalen-1-ylsulfonylamino)ethyl]-3-mercaptopropionamide (DansylC2SH), 1, was designed based on combining the inhibitory function of mercaptocarboxylate and a fluorophore. The binding of 1 to IMP-1 was investigated by fluorescence spectroscopy. Compound 1 can act as fluorescent probe for detecting IMP-1 selectively.

Graphical abstract: Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

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Article information

DOI
https://doi.org/10.1039/B209086D
Article type
Communication
Submitted
17 Sep 2002
Accepted
21 Oct 2002
First published
08 Nov 2002

Org. Biomol. Chem., 2003,1, 17-20

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Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

H. Kurosaki, H. Yasuzawa, Y. Yamaguchi, W. Jin, Y. Arakawa and M. Goto, Org. Biomol. Chem., 2003, 1, 17 DOI: 10.1039/B209086D

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