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Issue 1, 2003
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Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides

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Abstract

A brief, efficient and economical synthesis of the spiropyrrolidinyloxindoles, horsfiline and coerulescine, has been achieved, starting from itaconic acid and, respectively, p-anisidine or o-iodoaniline. Tandem radical cyclisation of iodoaryl alkenyl azides is the key step in both syntheses.

Graphical abstract: Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides

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Publication details

The article was received on 19 Aug 2002, accepted on 05 Sep 2002 and first published on 29 Nov 2002


Article type: Paper
DOI: 10.1039/B208114H
Org. Biomol. Chem., 2003,1, 117-122

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    Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides

    D. E. Lizos and J. A. Murphy, Org. Biomol. Chem., 2003, 1, 117
    DOI: 10.1039/B208114H

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