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Issue 5, 2003
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Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase

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Covering: 1989 to 2003

Polyhydroxyalkanoates (PHAs) are biodegradable polymers with properties of thermoplastics. Production of these polymers in an economically competitive fashion via bioengineering requires an understanding of the biosynthetic pathway and its regulation. This review summarizes our current knowledge of the mechanism of the class I and III PHA synthases: the initiation, elongation and termination processes. It also summarizes our current understanding of the phase transition from soluble substrates (coenzyme A esters of β-hydroxyalkanoates) to insoluble granules and our understanding of the requirement for a transcription factor, phasin proteins, and depolymerases in PHA homeostasis.

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Publication details

The article was received on 16 Jul 2003 and first published on 14 Aug 2003

Article type: Review Article
DOI: 10.1039/B209687K
Nat. Prod. Rep., 2003,20, 445-457

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    Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase

    J. Stubbe and J. Tian, Nat. Prod. Rep., 2003, 20, 445
    DOI: 10.1039/B209687K

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