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Issue 1, 2003
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Programmable modification of cell adhesion and zeta potential in silica microchips

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Abstract

Spatial patterning of thin polyacrylamide films bonded to self-assembled monolayers on silica microchannels is described as a means for manipulating cell-adhesion and electroosmotic properties in microchips. Streaming potential measurements indicate that the zeta potential is reduced by at least two orders of magnitude at biological pH, and the adhesion of several kinds of cells is reduced by 80–100%. Results are shown for cover slides and in wet-etched silica microchannels. Because the polyacrylamide film is thin and transparent, this film is consistent with optical manipulation of cells and detection of cell contents. The spatial patterning technique is straightforward and has the potential to aid on-chip analysis of single adherent cells.

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Article information


Submitted
28 Oct 2002
Accepted
10 Jan 2003
First published
06 Feb 2003

Lab Chip, 2003,3, 5-10
Article type
Paper

Programmable modification of cell adhesion and zeta potential in silica microchips

B. J. Kirby, A. R. Wheeler, R. N. Zare, J. A. Fruetel and T. J. Shepodd, Lab Chip, 2003, 3, 5
DOI: 10.1039/B210621N

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