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Issue 18, 2003
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Preparation of quinoxalines, dihydropyrazines, pyrazines and piperazines using tandem oxidation processes

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Abstract

α-Hydroxyketones undergo MnO2-mediated oxidation followed by in situ trapping with aromatic or aliphatic 1,2-diamines to give quinoxalines or dihydropyrazines, respectively, in a one pot procedure which avoids the need to isolate the highly reactive 1,2-dicarbonyl intermediates. Modifications of the procedure allow the formation of pyrazines and piperazines.

Graphical abstract: Preparation of quinoxalines, dihydropyrazines, pyrazines and piperazines using tandem oxidation processes

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Article information


Submitted
23 Jun 2003
Accepted
30 Jul 2003
First published
08 Aug 2003

Chem. Commun., 2003, 2286-2287
Article type
Communication

Preparation of quinoxalines, dihydropyrazines, pyrazines and piperazines using tandem oxidation processes

S. A. Raw, C. D. Wilfred and R. J. K. Taylor, Chem. Commun., 2003, 2286
DOI: 10.1039/B307177B

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