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Issue 14, 2003
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Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

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Abstract

A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

Graphical abstract: Gold(iii) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

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Article information


Submitted
26 Mar 2003
Accepted
21 May 2003
First published
16 Jun 2003

Chem. Commun., 2003, 1718-1719
Article type
Communication

Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

C. Che, R. W. Sun, W. Yu, C. Ko, N. Zhu and H. Sun, Chem. Commun., 2003, 1718
DOI: 10.1039/B303294A

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