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Issue 9, 2003
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Zn-Proline catalyzed direct aldol reaction in aqueous media

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Abstract

Zn complexes of proline, lysine and arginine are efficient catalysts for the aldol addition of p-nitrobenzaldehyde and acetone in aqueous medium, giving quantitative yields and enantiomeric excesses up to 56% with 5 mol% of the catalysts at room temperature.

Graphical abstract: Zn-Proline catalyzed direct aldol reaction in aqueous media

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Article information


Submitted
29 Jan 2003
Accepted
10 Mar 2003
First published
31 Mar 2003

Chem. Commun., 2003, 1090-1091
Article type
Communication

Zn-Proline catalyzed direct aldol reaction in aqueous media

T. Darbre and M. Machuqueiro, Chem. Commun., 2003, 1090
DOI: 10.1039/B301117H

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