Issue 6, 2003
From the journal:

Chemical Communications

Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers†

Jeongsoo Yoo,a   David E. Reicherta  and  Michael J. Welch*a  

* Corresponding authors

a Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO, USA
E-mail: welchm@mir.wustl.edu
Fax: 1 314 362 8399
Tel: 1 314 362 8436

Abstract

All possible configurations of two different groups on the four nitrogen atoms of cyclen were achieved using four differently protected cyclen intermediates including the novel mono-protected cyclen compound, mono-N-Cbz-cyclen.

Graphical abstract: Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers

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Article information

DOI
https://doi.org/10.1039/B212667B
Article type
Communication
Submitted
24 Dec 2002
Accepted
31 Jan 2003
First published
25 Feb 2003

Chem. Commun., 2003, 766-767

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Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers

J. Yoo, D. E. Reichert and M. J. Welch, Chem. Commun., 2003, 766 DOI: 10.1039/B212667B

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