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Issue 6, 2003
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Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers

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Abstract

All possible configurations of two different groups on the four nitrogen atoms of cyclen were achieved using four differently protected cyclen intermediates including the novel mono-protected cyclen compound, mono-N-Cbz-cyclen.

Graphical abstract: Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers

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Publication details

The article was received on 24 Dec 2002, accepted on 31 Jan 2003 and first published on 25 Feb 2003


Article type: Communication
DOI: 10.1039/B212667B
Chem. Commun., 2003, 766-767

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    Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers

    J. Yoo, D. E. Reichert and M. J. Welch, Chem. Commun., 2003, 766
    DOI: 10.1039/B212667B

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