Issue 2, 2003
From the journal:

Chemical Communications

Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation†

Siucheong Yan,a   Iris L. K. Wong,b   Larry M. C. Chowb  and  Hongzhe Sun*a  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Pokfulam Road, Hong Kong, P. R.. China
E-mail: hsun@hkucc.hku.hk
Fax: (+852) 2857 1586

b Department of Applied Biology and Chemical Technology and Central Laboratory of IMTDDS, The Hong Kong Polytechnic University, Kowloon, Hong Kong, P. R.. China

Abstract

The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.

Graphical abstract: Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation

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Article information

DOI
https://doi.org/10.1039/B210240D
Article type
Communication
Submitted
18 Oct 2002
Accepted
27 Nov 2002
First published
18 Dec 2002

Chem. Commun., 2003, 266-267

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Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation

S. Yan, I. L. K. Wong, L. M. C. Chow and H. Sun, Chem. Commun., 2003, 266 DOI: 10.1039/B210240D

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