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Issue 1, 2003
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Site-specific cleavage of human telomerase RNA using PNA-neocuproine·Zn(ii) derivatives

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Abstract

Here we report the synthesis of a novel PNA based neocuproine·Zn RNA cleaving agent; we demonstrate that such agents sequence specifically cleave a synthetic RNA target and in particular the RNA component of human telomerase.

Graphical abstract: Site-specific cleavage of human telomerase RNA using PNA-neocuproine·Zn(ii) derivatives

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Supplementary files

Article information


Submitted
16 Oct 2002
Accepted
11 Nov 2002
First published
26 Nov 2002

Chem. Commun., 2003, 36-37
Article type
Communication

Site-specific cleavage of human telomerase RNA using PNA-neocuproine·Zn(II) derivatives

A. Whitney, G. Gavory and S. Balasubramanian, Chem. Commun., 2003, 36
DOI: 10.1039/B210135A

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