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Issue 7, 2003
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Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences

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Abstract

The application of HPLC-MS combined with principal components analysis (PCA) to the metabonomic analysis of mouse urine is demonstrated. Urine samples from three strains of mouse were analysed by gradient HPLC-MS combined with positive and negative electrospray time-of-flight mass spectrometry. Analysis of the resulting data using PCA enabled the samples to be discriminated between on the basis of gender, strain and diurnal variation. These preliminary results suggest that HPLC-MS-based approaches may have a useful role in metabonomic analysis that complements existing approaches.

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Publication details

The article was received on 17 Apr 2003, accepted on 04 Jun 2003 and first published on 19 Jun 2003


Article type: Communication
DOI: 10.1039/B304296K
Analyst, 2003,128, 819-823

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    Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences

    R. Plumb, J. Granger, C. Stumpf, I. D. Wilson, J. A. Evans and E. M. Lenz, Analyst, 2003, 128, 819
    DOI: 10.1039/B304296K

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