Issue 18, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

1,2,4-Dithiazolidine-3,5-dione as an isocyanate equivalent in the Mitsunobu reaction

Mark E. Wood,*a   Daniel J. Cane-Honeysetta  and  Michael D. Dowleb  

* Corresponding authors

a School of Chemistry, University of Exeter, Stocker Road, Exeter, UK
E-mail: m.e.wood@exeter.ac.uk
Fax: +(44) 1392 263434
Tel: +(44) 1392 263450

b GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

Abstract

1,2,4-Dithiazolidine-3,5-dione 1 can be used as a nitrogen nucleophile in a modified Mitsunobu procedure to give N-alkylated products 2 which can be converted via isocyanates, into amine derivatives, under very mild conditions.

Graphical abstract: 1,2,4-Dithiazolidine-3,5-dione as an isocyanate equivalent in the Mitsunobu reaction

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Article information

DOI
https://doi.org/10.1039/B206793E
Article type
Communication
Submitted
11 Jul 2002
Accepted
08 Aug 2002
First published
19 Aug 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 2046-2047

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1,2,4-Dithiazolidine-3,5-dione as an isocyanate equivalent in the Mitsunobu reaction

M. E. Wood, D. J. Cane-Honeysett and M. D. Dowle, J. Chem. Soc., Perkin Trans. 1, 2002, 2046 DOI: 10.1039/B206793E

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