Chemoenzymic synthesis of oligosaccharide fragments of the capsular polysaccharide of Streptococcus pneumoniae type 14
Abstract
The chemoenzymic synthesis is described of β-D-Galp-(1→4)-β-D-Glcp-(1→6)-[(β-D-Galp)-(1→4)]-β-D-GlcpNAc-(1→3)-β-D-Galp-(1→O(CH2)6NH2) 20 and β-D-Galp-(1→4)-β-D-Glcp-(1→6)-[(β-D-Galp)-(1→4)]-β-D-GlcpNAc-(1→3)-β-D-Galp-(1→4)-β-D-Glcp-(1→O(CH2)6NH2) 21, representing penta- and hexasaccharide fragments of the Streptococcus pneumoniae type 14 capsular