Issue 18, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Homologation of α-amino acids to β-amino acids using Boc2O

Ganga-Ramu Vasanthakumar,a   Basanagoud S. Patila  and  Vommina V. Suresh Babu*a  

* Corresponding authors

a Department of Studies in Chemistry, Central College Campus, Dr. B. R. Ambedkar Veedhi, Bangalore University, Bangalore 560 001, India

Abstract

The use of Boc2O as a coupling agent in the homologation of N-urethane protected-α-amino acid to its β-homomers by the Arndt–Eistert method is described. The homologation gives good yields without racemization. The use of Boc2O as a coupling agent not only allows the easy scale up of the process but also it is cost effective.

Graphical abstract: Homologation of α-amino acids to β-amino acids using Boc2O

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Article information

DOI
https://doi.org/10.1039/B204652K
Article type
Paper
Submitted
14 May 2002
Accepted
23 Jul 2002
First published
22 Aug 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 2087-2089

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Homologation of α-amino acids to β-amino acids using Boc2O

G. Vasanthakumar, B. S. Patil and V. V. Suresh Babu, J. Chem. Soc., Perkin Trans. 1, 2002, 2087 DOI: 10.1039/B204652K

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