Issue 10, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis and analysis of peptide nucleic acid oligomers using Fmoc/acyl-protected monomers

Györgyi Kovács,*a   Zoltán Timár,a   Zoltán Kupihár,a   Zoltán Kelea  and  Lajos Kovács*a  

* Corresponding authors

a Department of Medicinal Chemistry, Dóm tér 8, University of Szeged, H-6720 Szeged, Hungary
E-mail: gyorgyi@ovrisc.mdche.u-szeged.hu, kovacs@ovrisc.mdche.u-szeged.hu
Fax: +36 62 54 59 71
Tel: +36 62 54 51 45

Abstract

The optimization of PNA oligomer synthesis has been accomplished employing Fmoc/acyl-protected monomers on TentaGel™ and Wang resins. Among the tested activating agents (CMP, BET, HATU) the latter was of choice in solid phase syntheses. “Leakage” of TentaGel™ resin greatly hampers the solution and MS analyses. Synthesis and acyl group deprotection steps have been separately examined using Wang resin. Optimal conditions also worked well on the CPG support. HPLC and MS analyses of the PNA oligomers were carried out under various conditions.

Graphical abstract: Synthesis and analysis of peptide nucleic acid oligomers using Fmoc/acyl-protected monomers

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Article information

DOI
https://doi.org/10.1039/B201297A
Article type
Paper
Submitted
05 Feb 2002
Accepted
05 Apr 2002
First published
23 Apr 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 1266-1270

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Synthesis and analysis of peptide nucleic acid oligomers using Fmoc/acyl-protected monomers

G. Kovács, Z. Timár, Z. Kupihár, Z. Kele and L. Kovács, J. Chem. Soc., Perkin Trans. 1, 2002, 1266 DOI: 10.1039/B201297A

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