Issue 1, 2002

A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A

Abstract

The enantiomerically pure cis-1,2-dihydrocatechol 7, which is obtained by microbial oxidation of chlorobenzene, has been converted, via a sequence of reactions including ring-closing metathesis and Yamaguchi lactonisation steps, into the natural product (−)-cladospolide A (1).

Graphical abstract: A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A

Article information

Article type
Communication
Submitted
05 Nov 2001
Accepted
14 Nov 2001
First published
03 Dec 2001

J. Chem. Soc., Perkin Trans. 1, 2002, 22-25

A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A

M. G. Banwell, K. A. Jolliffe, D. T. J. Loong, K. J. McRae and F. Vounatsos, J. Chem. Soc., Perkin Trans. 1, 2002, 22 DOI: 10.1039/B110018A

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