Issue 2, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Regioselective synthesis of pyrazolesvia the ring cleavage of 3-substituted N-alkylated 3-hydroxyisoindolin-1-ones

Kyu-Tae Chang,b   Yong Hyun Choi,†a   Seung-Ho Kim,a   Yong-Jin Yoon*c  and  Woo Song Lee*a  

* Corresponding authors

a Proteome Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea

b Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea

c Department of Chemistry & Research Institute of Natural Sciences, Gyeongsang National University, Chinju 660-701, Korea

Abstract

N-Alkyl (Me, Et, iPr, tBu)-substituted phthalimides 5 were easily transformed to mono-, di-, or tri-substituted pyrazoles 6via a one-pot addition–decyclisation–cyclocondensation process. The regiochemistry of the pyrazole ring was determined by X-ray crystallographic analysis and 1H NOE experiments.

Graphical abstract: Regioselective synthesis of pyrazoles via the ring cleavage of 3-substituted N-alkylated 3-hydroxyisoindolin-1-ones

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Article information

DOI
https://doi.org/10.1039/B108485M
Article type
Paper
Submitted
18 Sep 2001
Accepted
22 Nov 2001
First published
13 Dec 2001

J. Chem. Soc., Perkin Trans. 1, 2002, 207-210

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Regioselective synthesis of pyrazoles via the ring cleavage of 3-substituted N-alkylated 3-hydroxyisoindolin-1-ones

K. Chang, Y. H. Choi, S. Kim, Y. Yoon and W. S. Lee, J. Chem. Soc., Perkin Trans. 1, 2002, 207 DOI: 10.1039/B108485M

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