Regioselective acylation of 1-hydroxypyrazoles via metalated intermediates
Abstract
A range of C-4 and C-5 acylated 1-benzyloxypyrazoles (7a–e) and (4) have been prepared via Pd(0) catalysed cross-coupling between acid chlorides and
* Corresponding authors
a
ACADIA Pharmaceuticals A/S, Fabriksparken 58, DK-2600 Glostrup, Denmark
E-mail:
ns@acadia-pharm.com
Fax: +45 43293030
Tel: +45 43293000
b
The Royal Danish School of Pharmacy, Department of Medicinal Chemistry, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark
E-mail:
pv@dfh.dk
Fax: +45 35306040
Tel: +45 35306487
A range of C-4 and C-5 acylated 1-benzyloxypyrazoles (7a–e) and (4) have been prepared via Pd(0) catalysed cross-coupling between acid chlorides and
N. Østergaard, N. Skjærbæk, M. Begtrup and P. Vedsø, J. Chem. Soc., Perkin Trans. 1, 2002, 428 DOI: 10.1039/B107850J
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