Synthesis of histo blood-group antigens A and B (type 2), xenoantigen Galα1-3Galβ1-4GlNAc, and related type 2 backbone oligosaccharides as haptens in spacered form
Abstract
The partial α-fucosylation of spacered (sp = CH2CH2CH2NH2) N-acetyl β-lactosamine derivative having free hydroxy groups at C-3 and C-2' gives rise to oligosaccharides H (type 2), Lex and Ley, the first one was further elongated giving rise to A (type 2) or B (type 2) tetrasaccharides; spacered trisaccharides Galα1-3Galβ1-4GlNAc and Galα1-4Galβ1-4GlNAc were synthesised by the partial α-galactosylation of N-acetyl β-lactosamine derivative, having free hydroxy groups at C-4' and C-3'.