Accelerating water exchange for GdIII chelates by steric compression around the water binding site

Robert Ruloff; Éva Tóth; Rosario Scopelliti; Raphaël Tripier; Henri Handel; André E. Merbach

doi:10.1039/B207713B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Accelerating water exchange for Gd^III chelates by steric compression around the water binding site†

Robert Ruloff,^a Éva Tóth,^a Rosario Scopelliti,^a Raphaël Tripier,^b Henri Handel^b and André E. Merbach*^a

Author affiliations

* Corresponding authors

^a Ecole Polytechnique Fédérale de Lausanne, ICMB, BCH, Lausanne, Switzerland
E-mail: andre.merbach@epfl.ch
Fax: 41 21 693 9875
Tel: 41 21 693 9871

^b Université de Bretagne Occidentale, 6 av. Le Gorgeu, BP 809, 29285, Brest, France
E-mail: Henri.Handel@univ-brest.fr
Fax: 33 298 01 65 94
Tel: 33 298 01 79 27

Abstract

The water exchange process was accelerated for nine-coordinate, monohydrated macrocyclic Gd^III complexes by inducing steric compression around the water binding site; the increased steric crowding was achieved by replacing an ethylene bridge of DOTA⁴⁻ by a propylene bridge; in addition to the optimal water exchange rate, the stability of [Gd(TRITA)(H₂O)]⁻ is sufficiently high to ensure safe medical use which makes it a potential synthon for the development of high relaxivity, macromolecular MRI contrast agents.

Download options Please wait...

Supplementary files

Synthesis of TRITA and TRITA-bz-NO ₂- ¹⁷O relaxation rates and chemical shifts for Gd ^III chelates DOC (167K)

Article information

DOI: https://doi.org/10.1039/B207713B
Article type: Communication
Submitted: 07 Aug 2002
Accepted: 04 Oct 2002
First published: 23 Oct 2002

Download Citation

Chem. Commun., 2002, 2630-2631

Permissions

Request permissions

Accelerating water exchange for Gd^III chelates by steric compression around the water binding site

R. Ruloff, É. Tóth, R. Scopelliti, R. Tripier, H. Handel and A. E. Merbach, Chem. Commun., 2002, 2630 DOI: 10.1039/B207713B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications