Issue 16, 2002
From the journal:

Chemical Communications

Synthesis of a porphyrin-labelled carboranyl phosphate diester: a potential new drug for boron neutron capture therapy of cancer

Andreas Maderna,a   Ramon Huertas,a   M. Frederick Hawthorne,*a   Raymond Luguyab  and  M. Graça H. Vicente*b  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, USA
E-mail: mfh@chem.ucla.edu
Fax: (310)-825 5490
Tel: (310)-825 7378

b Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA
E-mail: vicente@lsu.edu
Fax: (225)-578 3458
Tel: (225)-578 7405

Abstract

A boron-rich, water-soluble porphyrin conjugate was synthesized by coupling of two carboranyl alcohols with 2-chlorophenoxyphosphorus dichloride, followed by conjugation to an amine-functionalized tetraphenyl-porphyrin via an amide linkage.

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Article information

DOI
https://doi.org/10.1039/B203730K
Article type
Communication
Submitted
16 Apr 2002
Accepted
23 May 2002
First published
15 Jul 2002

Chem. Commun., 2002, 1784-1785

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Synthesis of a porphyrin-labelled carboranyl phosphate diester: a potential new drug for boron neutron capture therapy of cancer

A. Maderna, R. Huertas, M. F. Hawthorne, R. Luguya and M. G. H. Vicente, Chem. Commun., 2002, 1784 DOI: 10.1039/B203730K

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