Enzyme-catalysed oxygenation and deoxygenation routes to chiral thiosulfinates

Derek R. Boyd; Narain D. Sharma; Martina A. Kennedy; Steven D. Shepherd; John F. Malone; André Alves-Areias; Robert Holt; Stig G. Allenmark; Malin A. Lemurell (née Andersson); Howard Dalton; Heather Luckarift

doi:10.1039/B203139F

Enzyme-catalysed oxygenation and deoxygenation routes to chiral thiosulfinates

Derek R. Boyd,*^a Narain D. Sharma,^a Martina A. Kennedy,^a Steven D. Shepherd,^a John F. Malone,^a André Alves-Areias,^a Robert Holt,^b Stig G. Allenmark,^c Malin A. Lemurell (née Andersson),^c Howard Dalton^d and Heather Luckarift^d

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* Corresponding authors

^a School of Chemistry, The Queen′s University of Belfast, Belfast, UK

^b Avecia Pharmaceuticals, Cleveland, Billingham, UK

^c Department of Chemistry, University of Göteborg, Göteborg, Sweden

^d Department of Biological Sciences, The University of Warwick, Coventry, UK

Abstract

Enantioenriched thiosulfinates have been obtained by dioxygenase- and chloroperoxidase-catalysed oxidation of 1,2-disulfides and dimethyl sulfoxide reductase- catalysed deoxygenation.

Chemical Communications

Enzyme-catalysed oxygenation and deoxygenation routes to chiral thiosulfinates

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Enzyme-catalysed oxygenation and deoxygenation routes to chiral thiosulfinates

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