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A new strategy towards the synthesis of phenanthridone alkaloids has been reported through the synthesis of (+)-2,7-dideoxypancratistatin from D-(−)-quinic acid employing PET initiated carbocyclization of an electron rich aromatics by silylenol ether as a key step.

Graphical abstract: A new strategy towards the total synthesis of phenanthridone alkaloids: synthesis of (+)-2,7-dideoxypancratistatin as a model study

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