Issue 3, 2002
From the journal:

Chemical Communications

Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

Kazunobu Toshima,*a   Ryusuke Takano,a   Tomohiro Ozawaa  and  Shuichi Matsumuraa  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Japan
E-mail: toshima@applc.keio.ac.jp
Fax: +81-45-566-1576

Abstract

Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5′ side guanine of 5′-GG-3′ site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline–carbohydrate) hybrid system was very effective for DNA cleavage.

Graphical abstract: Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

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Article information

DOI
https://doi.org/10.1039/B107829C
Article type
Communication
Submitted
03 Aug 2001
Accepted
03 Dec 2001
First published
08 Jan 2002

Chem. Commun., 2002, 212-213

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Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents

K. Toshima, R. Takano, T. Ozawa and S. Matsumura, Chem. Commun., 2002, 212 DOI: 10.1039/B107829C

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