Issue 12, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 2

5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties†

Florence Chalier*a  and  Paul Tordoa  

* Corresponding authors

a Laboratoire “Structure et Réactivité des Espèces Paramagnétiques”, UMR 6517, CNRS et Universités d'Aix-Marseille I et III, Faculté de Saint Jérôme, case 521, 13397 Marseille Cedex 20, France
E-mail: chalier@srepir1.univ-mrs.fr
Fax: (33) 4 91 28 85 12
Tel: (33) 4 91 28 85 62

Abstract

The nitrone DIPPMPO (5-diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide) was synthesised, isolated as hygroscopic crystals and its X-ray geometry was determined. The purification of DIPPMPO was easy, compared with that of DEPMPO (5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide) and its solutions in phosphate buffer were EPR silent. DIPPMPO exhibits all the advantages of DEPMPO for the spin-trapping of biological free radicals and thus DIPPMPO is a choice tool in this field.

Graphical abstract: 5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties

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Article information

DOI
https://doi.org/10.1039/B206909C
Article type
Paper
Submitted
15 Jul 2002
Accepted
10 Oct 2002
First published
12 Nov 2002

J. Chem. Soc., Perkin Trans. 2, 2002, 2110-2117

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5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties

F. Chalier and P. Tordo, J. Chem. Soc., Perkin Trans. 2, 2002, 2110 DOI: 10.1039/B206909C

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