Issue 4, 2002
From the journal:

Natural Product Reports

The biosynthesis of adenosylcobalamin (vitamin B12)

Martin J. Warren,*a   Evelyne Raux,a   Heidi L. Schubertb  and  Jorge C. Escalante-Semerenac  

* Corresponding authors

a School of Biological Sciences, Queen Mary, University of London, Mile End Road, London, UK
E-mail: m.j.warren@qmul.ac.uk
Fax: +44 20 7882 7609
Tel: +44 20 7882 7718

b Department of Biochemistry, University of Utah, Salt Lake City, Utah 84132, USA

c Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706-1521, USA

Abstract

Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited.

Graphical abstract: The biosynthesis of adenosylcobalamin (vitamin B12)

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Article information

DOI
https://doi.org/10.1039/B108967F
Article type
Review Article
Submitted
01 May 2002
First published
17 Jun 2002

Nat. Prod. Rep., 2002,19, 390-412

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The biosynthesis of adenosylcobalamin (vitamin B12)

M. J. Warren, E. Raux, H. L. Schubert and J. C. Escalante-Semerena, Nat. Prod. Rep., 2002, 19, 390 DOI: 10.1039/B108967F

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