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Issue 4, 2002
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The biosynthesis of adenosylcobalamin (vitamin B12)

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Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl). 183 references are cited.

Graphical abstract: The biosynthesis of adenosylcobalamin (vitamin B12)

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Publication details

The article was received on 01 May 2002 and first published on 17 Jun 2002

Article type: Review Article
DOI: 10.1039/B108967F
Nat. Prod. Rep., 2002,19, 390-412

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    The biosynthesis of adenosylcobalamin (vitamin B12)

    M. J. Warren, E. Raux, H. L. Schubert and J. C. Escalante-Semerena, Nat. Prod. Rep., 2002, 19, 390
    DOI: 10.1039/B108967F

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