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Issue 6, 2002
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Fluorinated amino acids in protein design and engineering

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Selective incorporation of unnatural amino acids into proteins is a powerful tool for illuminating the principles of protein design. In particular, fluorinated amino acids have recently emerged as valuable building blocks for designing hyperstable protein folds, as well as directing highly specific proteinprotein interactions. We review the collagen mimetic and coiled coil peptide systems that exemplify generalizable paradigms for future design. The unique electronic and phase properties of fluorocarbons are discussed, and protein synthesis using unnatural amino acids is briefly reviewed.

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The article was received on 23 May 2002 and first published on 13 Sep 2002

Article type: Review Article
DOI: 10.1039/B201097F
Chem. Soc. Rev., 2002,31, 335-341

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    Fluorinated amino acids in protein design and engineering

    N. C. Yoder and K. Kumar, Chem. Soc. Rev., 2002, 31, 335
    DOI: 10.1039/B201097F

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