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Issue 23, 2002
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Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine

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Abstract

The gene btrR from Bacillus circulans has been cloned and expressed and shown to produce a protein which catalyses the transamination of 2-deoxy-scyllo-inosose to give 2-deoxy-scyllo-inosamine, an intermediate in the biosynthesis of 2-deoxystreptamine.

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Submitted
08 Oct 2002
Accepted
21 Oct 2002
First published
05 Nov 2002

Chem. Commun., 2002, 2860-2861
Article type
Communication

Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine

F. Huang, Y. Li, J. Yu and J. B. Spencer, Chem. Commun., 2002, 2860
DOI: 10.1039/B209799K

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