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Issue 13, 2002
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Novel oxidation products from guanine nucleosides reacted with dimethyldioxirane

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Abstract

Treatment of guanosine or 2′-deoxyguanosine with dimethyldioxirane, followed by heating in aqueous solution, generates respectively 4-amidinocarbamoyl-5-hydroxyimidazole (1) or its 2-(2,3,4-trihydroxybutyl) derivative (2).

Graphical abstract: Novel oxidation products from guanine nucleosides reacted with dimethyldioxirane

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Article information


Submitted
07 Feb 2002
Accepted
09 May 2002
First published
24 May 2002

Chem. Commun., 2002, 1378-1379
Article type
Communication

Novel oxidation products from guanine nucleosides reacted with dimethyldioxirane

R. J. H. Davies, C. Stevenson, S. Kumar, J. Lyle, L. Cosby, J. F. Malone, D. R. Boyd, N. D. Sharma, A. P. Hunter and B. K. Stein, Chem. Commun., 2002, 1378
DOI: 10.1039/B201418C

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