Synthesis of a highly enantiomerically enriched silyllithium compound
Abstract
The highly enantiomerically enriched silyllithium compound lithiomethylphenyl(1-piperidinylmethyl)silane (4) reacts stereospecifically with chlorosilanes, but over a period of several hours slow racemization in solution at room temperature occurs, which can be supressed by a transmetalation reaction with MgBr2(thf)4.