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Issue 14, 2002
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Highly enantioselective alkynylation of aldehydes catalyzed by a readily available chiral amino alcohol-based ligand

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Abstract

A new inexpensive chiral amino alcohol-based ligand, (1S,2S)-2-N,N-dimethylamino-1-(p-nitrophenyl)-3-(t-butyldimethylsilyloxy)propane-1-ol, was developed for the asymmetric alkynylation of aliphatic and aromatic aldehydes, to prepare the corresponding propargylic alcohols in high yields with up to 99% ee.

Graphical abstract: Highly enantioselective alkynylation of aldehydes catalyzed by a readily available chiral amino alcohol-based ligand

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Article information


Submitted
25 Apr 2002
Accepted
28 May 2002
First published
14 Jun 2002

Chem. Commun., 2002, 1524-1525
Article type
Communication

Highly enantioselective alkynylation of aldehydes catalyzed by a readily available chiral amino alcohol-based ligand

B. Jiang, Z. Chen and W. Xiong, Chem. Commun., 2002, 1524
DOI: 10.1039/B203984B

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