Improved catalytic procedures for the copper(I)-promoted reactions of β-amido zinc reagents

Abstract

Copper-catalysed cross coupling of the β-aminoalkylzinc reagents 1a and 2 with unsaturated alkyl halides gives β-unsaturated ethylamines in 47–78% yield (4 examples) and enantiomerically pure β-unsaturated propylamines in 55–69% yield (3 examples). This method is more efficient for simple β-aminoalkylzinc reagents than that using stoichiometric copper.