Issue 1, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Cross-coupling reactions in Cinchona alkaloid chemistry: aryl-substituted and dimeric quinine, quinidine, as well as quincorine and quincoridine derivatives

Jens Frackenpohl,†a   Wilfried M. Braje‡a  and  H. Martin R. Hoffmann*a  

* Corresponding authors

a Department of Organic Chemistry, Universität Hannover, Schneiderberg 1B, Hannover, Germany
E-mail: hoffmann@mbox.oci.uni-hannover.de
Fax: +(0) 511 762 3011

Abstract

Cross-coupling reactions of modified Cinchona alkaloids provide access to a wide variety of novel arylated and dimeric derivatives of quinine and quinidine containing a single and double 1,2-amino alcohol functionality. Sonogashira and Heck reactions allow functionalization of ethynyl and 11-iodovinyl precursors. The role of bystander functionality is investigated.

Graphical abstract: Cross-coupling reactions in Cinchona alkaloid chemistry: aryl-substituted and dimeric quinine, quinidine, as well as quincorine and quincoridine derivatives

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B004693K
Article type
Paper
Submitted
13 Jun 2000
Accepted
28 Sep 2000
First published
11 Dec 2000

J. Chem. Soc., Perkin Trans. 1, 2001, 47-65

Permissions

Request permissions

Cross-coupling reactions in Cinchona alkaloid chemistry: aryl-substituted and dimeric quinine, quinidine, as well as quincorine and quincoridine derivatives

J. Frackenpohl, W. M. Braje and H. M. R. Hoffmann, J. Chem. Soc., Perkin Trans. 1, 2001, 47 DOI: 10.1039/B004693K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements