Issue 2, 2001

New approach to [a]-fused fluoroquinolones: the synthesis of 5-oxo-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinolines

Abstract

The reaction of N-(ethoxycarbonyl)methyl substituted ethyl 6,7-difluoro-, 6,7,8-trifluoro- and 5,6,7,8-tetrafluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylates with methyl methacrylate results in the [3 + 2] adducts, hexahydropyrrolo[1,2-a]quinolones, which can be precursors of [a]-fused fluoroquinolones.

Article information

Article type
Paper

Mendeleev Commun., 2001,11, 53-54

New approach to [a]-fused fluoroquinolones: the synthesis of 5-oxo-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinolines

E. Tsoi, V. N. Charushin, E. V. Nosova, G. N. Lipunova and A. V. Tkachev, Mendeleev Commun., 2001, 11, 53 DOI: 10.1070/MC2001v011n02ABEH001323

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