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Issue 5, 2001
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Abstract

Alkane (petroleum ether) vapor plasma technique was used for surface modification of chitosan membranes to control their permeation rate of water-soluble drugs and metabolites. Water contact angles of the chitosan surface increase from 13° to 23° after plasma treatment at 93 W for 60 min, and from 13° to 26° after plasma treatment at 119 W for 30 min, indicating reduced hydrophilicity of the membrane surface. Mechanical properties such as tensile strength and elongation-at-break of the chitosan membranes were also improved. In particular, there was a 6–7 fold increase in tensile strength in the wet state for the chitosan membrane treated at 93 W for 30 min. Permeation coefficients through the chitosan membrane plasma treated at 93 W for 30 min for urea, creatinine, uric acid, and cis-DDP decreased by 54.0%, 83.3%, 64.7% and 47.6%, respectively.

Graphical abstract: Surface modification of chitosan membranes by alkane vapor plasma

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Article information


Submitted
04 Dec 2000
Accepted
01 Mar 2001
First published
26 Mar 2001

J. Mater. Chem., 2001,11, 1374-1377
Article type
Paper

Surface modification of chitosan membranes by alkane vapor plasma

H. Wang, Y. Fang and Y. Yan, J. Mater. Chem., 2001, 11, 1374
DOI: 10.1039/B009688L

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