A novel host framework of cholic acid inclusion crystals by slide and flip of the layers

Nungruethai Yoswathananont; Suwabun Chirachanchai; Kohji Tashiro; Kazunori Nakano; Kazuki Sada; Mikiji Miyata

doi:10.1039/B101906F

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Nungruethai Yoswathananont,*^a Suwabun Chirachanchai,^b Kohji Tashiro,^c Kazunori Nakano,^d Kazuki Sada^a and Mikiji Miyata^a

Author affiliations

* Corresponding authors

^a Material and Life Science, Graduate School of Engineering, Yamadaoka, Suita, Osaka University, Osaka, Japan
E-mail: nun@ap.chem.eng.osaka-u.ac.jp, miyata@ap.chem.eng.osaka-u.ac.jp

^b The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, Thailand

^c Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan

^d Nagoya Municipal Industrial Research Institute, Rokuban, Atsuta-ku, Nagoya, Japan

Abstract

A novel host framework of cholic acid (CA) has been observed in the crystal structure of m-chloroaniline clathrate. Crystallographic study reveals that CA forms a bilayer-type structure; however, slide and flip of the lipophilic layers give a different host framework to those of over 100 inclusion crystals previously reported. Structural comparison between the clathrates of aniline and m-chloroaniline indicates that the addition of a chlorine atom leads to isomerization of the open host framework due to a steric effect between adjacent guests within the host cavities.

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Article information

DOI: https://doi.org/10.1039/B101906F
Article type: Paper
Submitted: 28 Feb 2001
Accepted: 09 Apr 2001

Download Citation

CrystEngComm, 2001,3, 74-77

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