Issue 24, 2001
From the journal:

Chemical Communications

Inductively coupled plasma mass spectrometry to identify proteindrug targets from whole cell systems†

Claire S. Allardyce,a   Paul J. Dyson,*a   Fadi R. Abou-Shakra,b   Heather Birtwistleb  and  Jonathan Coffeyb  

* Corresponding authors

a Department of Chemistry, The University of York, Heslington, York, UK
E-mail: pjd14@york.ac.uk

b Micromass UK Ltd, Atlas Park, Simonsway, Manchester, UK

Abstract

Proteins from cisplatin treated bacterial cells were partially separated by 1D polyacrylamide gel electrophoresis and analysed by laser ablation inductively coupled plasma mass spectrometry; using peptide fingerprinting methods central to proteomics, the band containing the highest levels of platinum was found to contain outer membrane protein A, which may be involved in cisplatin uptake.

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Article information

DOI
https://doi.org/10.1039/B108418F
Article type
Communication
Submitted
19 Sep 2001
Accepted
14 Nov 2001
First published
07 Dec 2001

Chem. Commun., 2001, 2708-2709

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Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systems

C. S. Allardyce, P. J. Dyson, F. R. Abou-Shakra, H. Birtwistle and J. Coffey, Chem. Commun., 2001, 2708 DOI: 10.1039/B108418F

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