Two pyrimidine (6-4) pyrimidone photoproduct derivatives, highly valuable to probe the substituent influence during polymerase replicative bypass, were prepared; one (1a) by diastereoselective Raney nickel reductive desulfurization of the s5(6-4) adduct of TpT (3) and the other (1b) by alkaline treatment of 1a.
Diastereoselective synthesis of 5 R and 5 S TT pyrimidine h5(6-4) pyrimidone photoproducts; structural analogues of the mutagenic UV-induced TT (6-4) photolesion
S. K. A. Matus, L. Quintero, J. Fourrey and P. Clivio, Chem. Commun., 2001, 2550 DOI: 10.1039/B107773M
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