A model complex of a possible intermediate in the mechanism of action of peptide deformylase: first example of an (N2S)zinc(II)–formate complex

SeChin Chang; Roger D. Sommer; Arnold L. Rheingold; David P. Goldberg

doi:10.1039/B106865M

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A model complex of a possible intermediate in the mechanism of action of peptide deformylase: first example of an (N₂S)zinc(ii)–formate complex†

SeChin Chang,^a Roger D. Sommer,^b Arnold L. Rheingold^b and David P. Goldberg*^a

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* Corresponding authors

^a Department of Chemistry, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD, USA.
E-mail: dpg@jhu.edu

^b Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA

Abstract

The synthesis and crystallographic characterization of a new (N₂S)zinc–alkyl complex and (N₂S)zinc–formate complex is described; the bonding mode of the formate complex has implications for the mechanism of action of the enzyme peptide deformylase.

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Article information

DOI: https://doi.org/10.1039/B106865M
Article type: Communication
Submitted: 30 Jul 2001
Accepted: 27 Sep 2001
First published: 02 Nov 2001

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Chem. Commun., 2001, 2396-2397

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A model complex of a possible intermediate in the mechanism of action of peptide deformylase: first example of an (N₂S)zinc(II)–formate complex

S. Chang, R. D. Sommer, A. L. Rheingold and D. P. Goldberg, Chem. Commun., 2001, 2396 DOI: 10.1039/B106865M

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