Non-uniform rate for platination of guanine-N7 located in short DNA oligomersElectronic supplementary information (ESI) available: observed pseudo-first-order and apparent second-order rate constants for platination of G-N7 located in short DNA oligomers. See http://www.rsc.org/suppdata/cc/b1/b103087f/

Abstract

The rate for adduct formation between cis-[Pt(NH₃)(c-NH₂C₆H₁₁)C l(OH₂)]⁺ and guanine-N7 in d(T_nGT_16−n) decreases gradually from the maximum rate found for platination of the middle position towards both the 3′ and 5′ ends.