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Issue 14, 2001
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Nonenzymatic kinetic resolution of β-amino alcohols: chiral BINAP mediated SN2 displacement of hydroxy groups by halogens through formation of an aziridinium ion intermediate

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Abstract

A series of optically active cyclic trans-β-amino alcohols were obtained (up to 97% ee) from nonenzymatic kinetic resolution of corresponding racemic amino alcohols using commercially available (S)-BINAP and NCS by halogenation of hydroxy groups through formation of a meso-aziridinium ion intermediate.

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Article information


Submitted
15 Mar 2001
Accepted
06 Jun 2001
First published
27 Jun 2001

Chem. Commun., 2001, 1314-1315
Article type
Communication

Nonenzymatic kinetic resolution of β-amino alcohols: chiral BINAP mediated SN2 displacement of hydroxy groups by halogens through formation of an aziridinium ion intermediate

G. Sekar and H. Nishiyama, Chem. Commun., 2001, 1314
DOI: 10.1039/B102460B

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