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Issue 10, 2001
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Taxol, a molecule for all seasons

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Abstract

The diterpenoid natural product taxol, first discovered in the 1960’s has proved to be the most important new anticancer drug introduced in the last ten years. A brief history of taxol’s development from laboratory curiosity to blockbuster drug is followed by a summary of its chemistry, including an overview of the six completed syntheses of taxol. The review concludes with a discussion of its bioactivity as a promoter of tubulin polymerization and as a drug.

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Article information


Submitted
03 Jan 2001
Accepted
19 Feb 2001
First published
26 Mar 2001

Chem. Commun., 2001, 867-880
Article type
Feature Article

Taxol, a molecule for all seasons

D. G. I. Kingston, Chem. Commun., 2001, 867 DOI: 10.1039/B100070P

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