Enantioselective separation of epoxides by capillary electrophoresis employing sulfated ß-cyclodextrin as chiral selector

Abstract

A capillary electrophoresis method was developed for the enantioseparation of epoxide compounds. Sulfated β-cyclodextrin was employed as a chiral selector. Phosphate–triethanolamine buffer showed a chiral separation effect when employing charged sulfated β-cyclodextrin. The effect of pH, triethanolamine concentration and sulfated β-cyclodextrin concentration on the resolution was studied. Methanol was tested as an organic modifier. Several other epoxides were successfully separated by the proposed method.