Issue 6, 2001
From the journal:

Analyst

Synthesis of 5-fluorouracil-imprinted

Akimitsu Kugimiya,a   Takasi Mukawaa  and  Toshifumi Takeuchi*a  

* Corresponding authors

a Laboratory of Synthetic Biochemistry, Faculty of Information Sciences, Hiroshima City University, 3-4-1 Ozuka-higashi, Asaminami-ku, Hiroshima, Japan.
E-mail: takeuchi@im.hiroshima-cu.ac.jp;
Fax: +81 82 8301610
Tel: +81 82 8301603

Abstract

The antitumor active compound 5-fluorouracil (5-FU) was used as a target molecule and 5-FU-imprinted polymers were synthesized using 2,6-bis(acrylamido)pyridine and/or 2-(trifluoromethyl)acrylic acid as functional monomers. The 5-FU-imprinted polymers showed a higher affinity for 5-FU than that for 5-FU derivatives. By using both functional monomers simultaneously, the affinity and separation for 5-FU were improved.

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Article information

DOI
https://doi.org/10.1039/B010056K
Article type
Paper
Submitted
18 Dec 2000
Accepted
01 Mar 2001
First published
30 Apr 2001

Analyst, 2001,126, 772-774

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Synthesis of 5-fluorouracil-imprinted polymers with multiple hydrogen bonding interactions

A. Kugimiya, T. Mukawa and T. Takeuchi, Analyst, 2001, 126, 772 DOI: 10.1039/B010056K

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