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Issue 19, 2001
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Platinum binding to DNA: structural controls and consequences

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Abstract

In recent years there have been numerous major advances in the understanding of the factors controlling all aspects of platinum binding to DNA and of the consequences of DNA binding. The interaction with DNA involves numerous stages, including: aquation of the complex, preassociation with the DNA, monofunctional adduct formation, closure to a bifunctional adduct, distortion of the DNA and recognition of this distortion. In this review we outline how the recent advances have increased our understanding of the factors controlling each of these steps and the implications for rational drug development.

Graphical abstract: Platinum binding to DNA: structural controls and consequences

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Article information


Submitted
20 Jun 2001
Accepted
14 Aug 2001
First published
13 Sep 2001

J. Chem. Soc., Dalton Trans., 2001, 2711-2718
Article type
Perspective

Platinum binding to DNA: structural controls and consequences

T. W. Hambley, J. Chem. Soc., Dalton Trans., 2001, 2711
DOI: 10.1039/B105406F

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