Issue 6, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 2

New molecular catalysts for ATP cleavage. Criteria of size complementarity

Juan A. Aguilar,a   Ana B. Descalzo,b   Pilar Díaz,b   Vieri Fusi,c   Enrique García-España,b   Santiago V. Luis,d   Mauro Micheloni,c   José A. Ramírez,b   Paolo Romanic  and  Conxa Sorianoa  

a Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Burjassot (Valencia), Spain

b Departamento de Química Inorgánica, Facultad de Química, Universidad de Valencia, C/ Dr. Moliner 50, Burjassot (Valencia), Spain
E-mail: enrique.garcia-es@uv.es

c Instituto di Scienze Chimiche, Università di Urbino, P.za Rinascimento 6, Urbino, Italia

d Departamento de Química Orgánica e Inorgánica, Universidad Jaume I, 12080, Castellón, Spain

Abstract

The interaction of the cyclophane receptor 2,5,8,11,14,17-hexaaza[18]metacyclophane (L) with the nucleotides ATP, ADP and AMP is described. L yields one of the largest rate enhancements for hydrolytic ATP cleavage observed in macrocyclic polyamines. The process is specific for the formation of ADP and involves a high degree of geometrical complementarity between host and guest species. The analogue compound 24-hydroxy-2,5,8,11,14,17-hexaaza[18]metacyclophane (L11) shows also a high degree of ATP activation. However, in this case deprotonation of the hydroxy group results in almost complete quenching of the ATPase activity above pH 7.0.

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Article information

DOI
https://doi.org/10.1039/B000606H
Article type
Paper
Submitted
21 Jan 2000
Accepted
17 Mar 2000
First published
09 May 2000

J. Chem. Soc., Perkin Trans. 2, 2000, 1187-1192

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New molecular catalysts for ATP cleavage. Criteria of size complementarity

J. A. Aguilar, A. B. Descalzo, P. Díaz, V. Fusi, E. García-España, S. V. Luis, M. Micheloni, J. A. Ramírez, P. Romani and C. Soriano, J. Chem. Soc., Perkin Trans. 2, 2000, 1187 DOI: 10.1039/B000606H

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